This brief offers insight into the role of headquarters recruitment in economic development and South Carolina’s present condition in this area. Headquarters recruitment is an economic development tactic that fosters the creation or relocation of firms’ administrative and management units in a particular locale. Such efforts also focus on the retention of existing corporate headquarters. As a strategy, headquarters recruitment is underexploited in South Carolina, but it merits consideration as previous studies point to a number of ways in which a city or region benefits from hosting headquarters.